MC2 receptor (acthr_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R (ACTHR)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
K
H
I
I
N
S
Y
E
N
10
                   
I
N
N
T
A
R
N
N
S
D
20
            TM1  
C
P
R
V
V
L
P
E
E
I
30
                   
F
F
T
I
S
I
V
G
V
L
40
                   
E
N
L
I
V
L
L
A
V
F
50
    ICL1 TM2  
K
N
K
N
L
Q
A
P
M
Y
60
                   
F
F
I
C
S
L
A
I
S
D
70
                   
M
L
G
S
L
Y
K
I
L
E
80
                   
N
I
L
I
I
L
R
N
M
G
90
ECL1   TM3    
Y
L
K
P
R
G
S
F
E
T
100
                   
T
A
D
D
I
I
D
S
L
F
110
                   
V
L
S
L
L
G
S
I
F
S
120
                   
L
S
V
I
A
A
D
R
Y
I
130
        ICL2    
T
I
F
H
A
L
R
Y
H
S
140
    TM4          
I
V
T
M
R
R
T
V
V
V
150
                   
L
T
V
I
W
T
F
C
T
G
160
                   
T
G
I
T
M
V
I
F
S
H
170
TM5              
H
V
P
T
V
I
T
F
T
S
180
                   
L
F
P
L
M
L
V
F
I
L
190
                   
C
L
Y
V
H
M
F
L
L
A
200
                   
R
S
H
T
R
K
I
S
T
L
210
ICL3 TM6      
P
R
A
N
M
K
G
A
I
T
220
                   
L
T
I
L
L
G
V
F
I
F
230
                   
C
W
A
P
F
V
L
H
V
L
240
          ECL3 TM7
L
M
T
F
C
P
S
N
P
Y
250
               
C
A
C
Y
M
S
L
F
Q
V
260
                   
N
G
M
L
I
M
C
N
A
V
270
                   
I
D
P
F
I
Y
A
F
R
S
280
H8                
P
E
L
R
D
A
F
K
K
M
290
        C-term
I
F
C
S
R
Y
W

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 K N L Q ICL1ECL1 Y L K P R ECL1ICL2 A L R Y H S I V ICL2ECL2 H ECL2ICL3 T L P R A ICL3ECL3 P S ECL3N-term M K H I I N S Y E N I N N T A R N N S D C P R V V L N-termC-term R Y W C-term P E E I F F T I S I V G V L E N L I V L L A V F K N A P M Y F F I C S L A I S D M L G S L Y K I L E N I L I I L R N M G G S F E T T A D D I I D S L F V L S L L G S I F S L S V I A A D R Y I T I F H T M R R T V V V L T V I W T F C T G T G I T M V I F S H V P T V I T F T S L F P L M L V F I L C L Y V H M F L L A R S H T R K I S N M K G A I T L T I L L G V F I F C W A P F V L H V L L M T F C N P Y C A C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E F K K S L R D A M I F C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L V G V I S I T F F I E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 V S L S F I S G L L S L V F L S D I I D 3 T V V V L T V I W T F C T G T G I T M V 4 Y L C L I F V L M L P F L S T F T I V T 5 T I L L G V F I F C W A P F V L H V L L 6 F P D I V A N C M I L M G N V Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

60 mutation data points available.

PHYSIOLOGICAL LIGANDS

ACTH

STRUCTURE MODELS

acthr_human inactive,

acthr_human active

STRUCTURES

Found 1 structure(s) - view all details on the Structures page

PDBs: 8GY7